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Anti-epilepsy drugs linked to Suicide
Wellington, Feb 1 NZPA - Health officials are warning the public about anti-epileptic medicines that can cause suicidal thoughts or behaviour. The medicines were used to treat epilepsy, bipolar disorder, migraine headaches and other conditions, government drug safety watchdog Medsafe said today.

The alert followed a similar statement issued by the US Food and Drug Administration (FDA) which was posted on the Medsafe website. The warnings were based on studies that showed for every 1000 people taking the medicines, on average an additional two people would have suicidal thoughts or behaviours.

"We are providing doctors and health care professionals with the FDA's advice so they can inform patients and their families about the risk of suicide as a result of taking these medicines," Medsafe's interim manager Stewart Jessamine said.

"In the meantime, we advise patients to consult their doctor before making any changes to the medicines they're taking."

People taking the medicines and those caring for them should be on the lookout for any unusual changes in behaviour, he said.

The anti-convulsant medicines approved for use in New Zealand are:

* Phenobarbital (brand name Phenobarbitone);

* Phenytoin sodium (Dilantin);

* Ethosuximide (Zarontin);

* Carbamazepine (Tegretol, Tegretol CR,Teril);

* Oxcarbazepine (Trileptal);

* Sodium valproate (Epilim);

* Tiagabine (Gabitril);

* Vigabatrin (Sabril);

* Gabapentin (Apo-Gabapentin, Arrow-Gabapentin, Neurontin, Nupentin);

* Topiramate (Apo-Topiramate, Topamax);

* Lamotrigine (Arrow-Lamotrigine, Lamictil, Lamitor DT, Logem, Mogine, Motrig);

* Levetiracetam (Keppra);

* Pregabalin (Lyrica); and

* Primidone (Apo-Primidone).

NZPA WGT rq n


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